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Ube2atm1Agr
Targeted Allele Detail
Nomenclature
Symbol: Ube2atm1Agr
Name: ubiquitin-conjugating enzyme E2A; targeted mutation 1, J Anton Grootegoed
MGI ID: MGI:2450874
Synonyms: HR6A-, mHR6A-
Gene: Ube2a  Location: ChrX:36873900-36884222 bp, + strand  Genetic Position: ChrX, 21.28 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81811
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe ORF was disrupted immediately after the ATG as a neo was inserted in place of sequence encoding amino acids 3-14 in exon 1. PCR confirmed recombination in mutant mice and RT-PCR indicated lack of transcript in mouse testis. (J:91848)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ube2a Mutation:  4 strains or lines available
References
Original:  J:81811 Baarends WM, et al., Loss of HR6B Ubiquitin-Conjugating Activity Results in Damaged Synaptonemal Complex Structure and Increased Crossing-Over Frequency during the Male Meiotic Prophase. Mol Cell Biol. 2003 Feb;23(4):1151-62
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory