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Tyrobptm1Ttk
Targeted Allele Detail
Nomenclature
Symbol: Tyrobptm1Ttk
Name: TYRO protein tyrosine kinase binding protein; targeted mutation 1, Toshiyuki Takai
MGI ID: MGI:2450834
Synonyms: DAP12-, DAP12KO, DAP12 KO, Tyrobp-
Gene: Tyrobp  Location: Chr7:30413788-30417577 bp, + strand  Genetic Position: Chr7, 17.45 cM, cytoband B
Osteopetrosis in Tyrobptm1Ttk/Tyrobptm1Ttk mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81823
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tyrobp Mutation:  3 strains or lines available
References
Original:  J:81823 Kaifu T, et al., Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J Clin Invest. 2003 Feb;111(3):323-32
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory