Tyrobp^tm1Ttk
Targeted Allele Detail

Summary

• Symbol: Tyrobp^tm1Ttk
• Name: TYRO protein tyrosine kinase binding protein; targeted mutation 1, Toshiyuki Takai
• MGI ID: MGI:2450834
• Synonyms: DAP12^-, DAP12^KO, DAP12 KO, Tyrobp^-
• Gene: Tyrobp Location: Chr7:30113207-30117007 bp, + strand Genetic Position: Chr7, 17.45 cM, cytoband B
• Alliance: Tyrobp^tm1Ttk page

Osteopetrosis in Tyrobp^tm1Ttk/Tyrobp^tm1Ttk mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81823
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of the promoter region and exons 1-3 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of lymphokine-activated killer (LAK) cell protein extracts. (J:81823)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tyrobp Mutation: 10 strains or lines available

References

• Original: J:81823 Kaifu T, et al., Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J Clin Invest. 2003 Feb;111(3):323-32
• All: 53 reference(s)