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Targeted Allele Detail
Symbol: Apba1tm1.1Sud
Name: amyloid beta (A4) precursor protein binding, family A, member 1; targeted mutation 1.1, Thomas C Sudhof
MGI ID: MGI:2450729
Synonyms: Mint 1 knockout, Mint1 KO
Gene: Apba1  Location: Chr19:23758887-23949596 bp, + strand  Genetic Position: Chr19, 18.45 cM
Germline Transmission:  Earliest citation of germline transmission: J:81845
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsFloxed exon 1 was subsequently removed by crossing mutant animals to a cre deleter strain. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of brain proteins. (J:81845)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apba1 Mutation:  3 strains or lines available
Original:  J:81845 Ho A, et al., A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1409-14
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory