Lipg^tm1Tq
Targeted Allele Detail

Summary

• Symbol: Lipg^tm1Tq
• Name: lipase, endothelial; targeted mutation 1, Thomas Quertermous
• MGI ID: MGI:2450672
• Synonyms: LIPG^-
• Gene: Lipg Location: Chr18:75072393-75094334 bp, - strand Genetic Position: Chr18, 50.94 cM, cytoband E2
• Alliance: Lipg^tm1Tq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81821
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 1 via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of lung, kidney, aorta, liver, and heart. (J:81821)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lipg Mutation: 29 strains or lines available

References

• Original: J:81821 Ishida T, et al., Endothelial lipase is a major determinant of HDL level. J Clin Invest. 2003 Feb;111(3):347-55
• All: 13 reference(s)