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Hbatm1Paz
Targeted Allele Detail
Nomenclature
Symbol: Hbatm1Paz
Name: hemoglobin alpha chain complex; targeted mutation 1, Chris Paszty
MGI ID: MGI:2450531
Synonyms: Hba0, Hba1-2del
Gene: Hba  Location: unknown  Genetic Position: Chr11, cytoband A
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:28392
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsBoth of the adult hemoglobin genes, alpha 1 and alpha 2, and the region between them were deleted and replaced with a neomycin resistance cassette by homologous recombination. (J:28392)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hba Mutation:  13 strains or lines available
References
Original:  J:28392 Paszty C, et al., Lethal alpha-thalassaemia created by gene targeting in mice and its genetic rescue. Nat Genet. 1995 Sep;11(1):33-9
All:  69 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory