Sptbn1tm1Mish
Targeted Allele Detail
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Symbol: |
Sptbn1tm1Mish |
Name: |
spectrin beta, non-erythrocytic 1; targeted mutation 1, Lopa Mishra |
MGI ID: |
MGI:2450327 |
Synonyms: |
Beta2SP-, Elf- |
Gene: |
Sptbn1 Location: Chr11:30049395-30218175 bp, - strand Genetic Position: Chr11, 17.44 cM
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Beckwith-Wiedemann Syndrome-like phenotypes in Sptbn1tm1Mish/Spnb2+ mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:81747
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 2.2 kb fragment containing the 25th exon was replaced with a neomycin selection cassette. The deleted region encodes 114 amino acids that make up the a portion of the ankyrin binding domain. Western blot analysis of homozygous mutant embryos indicated an absence of normal protein.
(J:81747)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Sptbn1 Mutation: |
99 strains or lines available
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Original: |
J:81747 Tang Y, et al., Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. Science. 2003 Jan 24;299(5606):574-7 |
All: |
13 reference(s) |
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