About   Help   FAQ
Tg(Tek-cre)1Ywa
Transgene Detail
Summary
Symbol: Tg(Tek-cre)1Ywa
Name: transgene insertion 1, Masashi Yanagisawa
MGI ID: MGI:2450311
Synonyms: T2Cre, TekCre, Tie2Cre, Tie-2 Cre, Tie2-Cre, Tie2Cre+
Transgene: Tg(Tek-cre)1Ywa  Location: unknown  Genetic Position: Chr5, Syntenic
Alliance: Tg(Tek-cre)1Ywa page
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Hypomorph, Recombinase)
Mutations:    Insertion, Intragenic deletion
  Tg(Tek-cre)1Ywa involves 1 genes/genome features (Sorcs2) View all
 
Mutation detailsThis transgene expresses Cre recombinase under the control of a mouse Tek promoter and enhancer. This promoter is active in endothelial cells. Insertion within intron 1 of Sorcs2 results in the 204 bp deletion (36382105 to 36382309 on mouse chromosome 5; GRCm37/mm9 genome build) leading to reduced and variable expression. (J:67365, J:71269, J:242313)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tek (mouse)
Summary of all recombinase alleles driven by Tek.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 173 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Tg(Tek-cre)1Ywa
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
References
Original:  J:67365 Kisanuki YY, et al., Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev Biol. 2001 Feb 15;230(2):230-42
All:  679 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
11/15/2022
MGI 6.22
The Jackson Laboratory