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Chattm1Fhg
Targeted Allele Detail
Nomenclature
Symbol: Chattm1Fhg
Name: choline acetyltransferase; targeted mutation 1, Fred H Gage
MGI ID: MGI:2450310
Synonyms: ChAT(-)
Gene: Chat  Location: Chr14:32408203-32465909 bp, - strand  Genetic Position: Chr14, 19.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81738
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 11, 12, and 13 were replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by immunostaining of the basal forebrain of homozygous mutant embryos. Assays of the brain stem, spinal cord, and septum showed an absence of endogenous activity. (J:81738)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chat Mutation:  17 strains or lines available
References
Original:  J:81738 Brandon EP, et al., Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient mice. J Neurosci. 2003 Jan 15;23(2):539-49
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory