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Rb1tm3Tyj
Targeted Allele Detail
Nomenclature
Symbol: Rb1tm3Tyj
Name: RB transcriptional corepressor 1; targeted mutation 3, Tyler Jacks
MGI ID: MGI:2450162
Synonyms: cRblox, Rb12lox, Rbc, Rbf, RbloxP
Gene: Rb1  Location: Chr14:73183673-73325822 bp, - strand  Genetic Position: Chr14, 38.73 cM, cytoband D3
Increase in ploidy in hepatocytes of tamoxifen-treated Rb1tm3Tyj/Rb1tm3Tyj Tg(tetO-MYC)36aBop/0 Tg(Cebpb-tTA)5Bjd/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81643
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Single loxP sites flank exon 3. (J:81643)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Rb1 Mutation:  70 strains or lines available
References
Original:  J:81643 MacPherson D, et al., Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system. Mol Cell Biol. 2003 Feb;23(3):1044-53
All:  66 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory