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Hnf1atm2Ylee
Targeted Allele Detail
Nomenclature
Symbol: Hnf1atm2Ylee
Name: HNF1 homeobox A; targeted mutation 2, Ying-Hue Lee
MGI ID: MGI:2450154
Synonyms: Hnf-1alphakin
Gene: Hnf1a  Location: Chr5:114948980-114971094 bp, - strand  Genetic Position: Chr5, 55.99 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81639
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA floxed PGK-neo cassette was inserted into intron 1 by homologous recombination. Transcript was undetected by Northern blot analysis of homozygous mutant liver tissue. The rescue of the allele was demonstrated by tissue-specific expression of cre. Northern blot analysis verified the presence of transcript in the livers of in rescued mice. (J:81639)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hnf1a Mutation:  16 strains or lines available
References
Original:  J:81639 Lee YH, et al., Liver-specific reactivation of the inactivated Hnf-1alpha gene: elimination of liver dysfunction to establish a mouse MODY3 model. Mol Cell Biol. 2003 Feb;23(3):923-32
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory