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Targeted Allele Detail
Symbol: Nfictm1Rmg
Name: nuclear factor I/C; targeted mutation 1, Richard M Gronostajski
MGI ID: MGI:2450153
Synonyms: Nfic-, NFI-C-
Gene: Nfic  Location: Chr10:81396191-81431919 bp, - strand  Genetic Position: Chr10, 39.72 cM, cytoband C1
Germline Transmission:  Earliest citation of germline transmission: J:81645
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1.3 kb fragment encompassing exon 2 and flanking intronic sequence was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded both the DNA-binding and dimerization domains. An aberrant transcript resulting from a splice of exon 1 to exon 3 was identified by RT-PCR analysis of homozygous mutant liver and brain tissues. Sequence analysis indicated that the mutant transcript is out of frame and terminates in exon 3, encoding a polypeptide comprised of 31 residues. (J:81645)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfic Mutation:  19 strains or lines available
Original:  J:81645 Steele-Perkins G, et al., Essential role for NFI-C/CTF transcription-replication factor in tooth root development. Mol Cell Biol. 2003 Feb;23(3):1075-84
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory