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Apctm3Mmt
Targeted Allele Detail
Nomenclature
Symbol: Apctm3Mmt
Name: APC, WNT signaling pathway regulator; targeted mutation 3, Makoto M Taketo
MGI ID: MGI:2449944
Synonyms: ApcneoR
Gene: Apc  Location: Chr18:34220924-34322552 bp, + strand  Genetic Position: Chr18, 18.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81402
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutation:    Insertion
 
Mutation detailsLoxP sites flanking exons 11-13 were introduced and a neomycin resistance gene was inserted downstream of exon 13 in the direction opposite of transcription. RT-PCR analysis of heterozygous and homozygous mutant animals showed reduced gene expression at approximately 55% and 20% that of wild-type, respectively. This is a hypomorphic allele. (J:81402)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 29 assay results
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  58 strains or lines available
References
Original:  J:81402 Ishikawa TO, et al., Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo. Dev Biol. 2003 Jan 15;253(2):230-46
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory