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Dnase2atm1Osa
Targeted Allele Detail
Nomenclature
Symbol: Dnase2atm1Osa
Name: deoxyribonuclease II alpha; targeted mutation 1, Shigekazu Nagata
MGI ID: MGI:2449811
Synonyms: Dnase II-
Gene: Dnase2a  Location: Chr8:84908560-84922915 bp, + strand  Genetic Position: Chr8, 41.31 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69831
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1-5 and part of exon 6 were replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression was confirmed by Northern blot analysis of fetal liver RNA from E14.5 homozygous mutant embryos. No enzyme activity could be detected in homozygous mutant fetal liver extracts. (J:69831)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 24 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dnase2a Mutation:  69 strains or lines available
References
Original:  J:69831 Kawane K, et al., Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver. Science. 2001 May 25;292(5521):1546-9
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/13/2015
MGI 5.21
The Jackson Laboratory