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Dffbtm1Osa
Targeted Allele Detail
Nomenclature
Symbol: Dffbtm1Osa
Name: DNA fragmentation factor, beta subunit; targeted mutation 1, Shigekazu Nagata
MGI ID: MGI:2449797
Synonyms: CAD-
Gene: Dffb  Location: Chr4:154048904-154059578 bp, - strand  Genetic Position: Chr4, 83.78 cM, cytoband E2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81474
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1-6 and part of exon 7 were replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis of spleen and thymus RNA from homozygous mutant animals did not detect gene expression. (J:81474)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dffb Mutation:  21 strains or lines available
References
Original:  J:81474 Kawane K, et al., Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation. Nat Immunol. 2003 Feb;4(2):138-44
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory