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Targeted Allele Detail
Symbol: Opn4tm1Yau
Name: opsin 4 (melanopsin); targeted mutation 1, King-Wai Yau
MGI ID: MGI:2449781
Synonyms: MKO, mop-, Opn4-, Opn4taulac, Opn4tau-lacZ
Gene: Opn4  Location: Chr14:34590618-34600142 bp, - strand  Genetic Position: Chr14, 20.83 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:81604
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsThe endogenous locus was disrupted by the insertion of a cassette containing tau-lacZ and floxed PGK-neo immediately downstream of the endogenous start codon. Beta-galactosidase activity verified the expression of lacZ. (J:81604)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 30 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Opn4 Mutation:  1 strain or line available
Original:  J:81604 Hattar S, et al., Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science. 2002 Feb 8;295(5557):1065-70
All:  67 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory