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Targeted Allele Detail
Symbol: Opn4tm1Ruby
Name: opsin 4 (melanopsin); targeted mutation 1, Norman F Ruby
MGI ID: MGI:2449696
Gene: Opn4  Location: Chr14:34590618-34600142 bp, - strand  Genetic Position: Chr14, 20.83 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:81502
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 3 was disrupted by the insertion of a cassette containing IRES-betageo. The deleted region consisted of 38 bp encoding a portion of the predicted transmembrane domain 2 (amino acids 116-128). X-gal staining showed expression of lacZ in occasional cells of the ganglion cell layer. (J:81502)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Opn4 Mutation:  1 strain or line available
Original:  J:81502 Ruby NF, et al., Role of melanopsin in circadian responses to light. Science. 2002 Dec 13;298(5601):2211-3
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory