About   Help   FAQ
Opn4tm1Ruby
Targeted Allele Detail
Nomenclature
Symbol: Opn4tm1Ruby
Name: opsin 4 (melanopsin); targeted mutation 1, Norman F Ruby
MGI ID: MGI:2449696
Gene: Opn4  Location: Chr14:34590618-34600142 bp, - strand  Genetic Position: Chr14, 20.83 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81502
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 was disrupted by the insertion of a cassette containing IRES-betageo. The deleted region consisted of 38 bp encoding a portion of the predicted transmembrane domain 2 (amino acids 116-128). X-gal staining showed expression of lacZ in occasional cells of the ganglion cell layer. (J:81502)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Opn4 Mutation:  1 strain or line available
References
Original:  J:81502 Ruby NF, et al., Role of melanopsin in circadian responses to light. Science. 2002 Dec 13;298(5601):2211-3
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/18/2020
MGI 6.14
The Jackson Laboratory