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Opn4tm1Skay
Targeted Allele Detail
Nomenclature
Symbol: Opn4tm1Skay
Name: opsin 4 (melanopsin); targeted mutation 1, Steve A Kay
MGI ID: MGI:2449695
Synonyms: Opn4-, Opn4neo
Gene: Opn4  Location: Chr14:34590618-34600142 bp, - strand  Genetic Position: Chr14, 20.83 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81501
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S1/SvImJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by immunocytochemical analysis of homozygous mutant retinal tissue. (J:81501)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Opn4 Mutation:  1 strain or line available
References
Original:  J:81501 Panda S, et al., Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting. Science. 2002 Dec 13;298(5601):2213-6
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory