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Ntan1tm1Avar
Targeted Allele Detail
Nomenclature
Symbol: Ntan1tm1Avar
Name: N-terminal Asn amidase; targeted mutation 1, Alexander Varshavsky
MGI ID: MGI:2449464
Synonyms: Ntan1-
Gene: Ntan1  Location: Chr16:13818845-13835451 bp, + strand  Genetic Position: Chr16, 9.64 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62140
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exons 2-5 with a PGK-neo cassette via homologous recombination. Northern blot analysis detected no expression in brains of homozygous mutant animals, but testes mRNA contained transcripts which apparently lack the 5' half of the open reading frame. Whole mount in-situ hybridization analysis of E9.75 homozygous mutant embryos did not detect any gene expression. (J:62140)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 20 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntan1 Mutation:  13 strains or lines available
References
Original:  J:62140 Kwon YT, et al., Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway. Mol Cell Biol. 2000 Jun;20(11):4135-48
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory