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Psen1tm2.1Shn
Targeted Allele Detail
Nomenclature
Symbol: Psen1tm2.1Shn
Name: presenilin 1; targeted mutation 2.1, Jie Shen
MGI ID: MGI:2449306
Synonyms: PS1delta
Gene: Psen1  Location: Chr12:83688203-83735199 bp, + strand  Genetic Position: Chr12, 38.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71606
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA single loxP site was inserted into intron 1 and a loxP-flanked hygromycin and thymidine kinase selection cassette was inserted into intron 3. Exons 2 and 3 and the drug selection cassette were removed in ES cells by transient Cre expression in ES cells prior to the production of mice. The final allele has a single loxP site in place of exons 2 and 3. (J:71606)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Psen1 Mutation:  22 strains or lines available
References
Original:  J:71606 Yu H, et al., App processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron. 2001 Sep 13;31(5):713-26
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory