Igf1^tm1.1Dlr
Targeted Allele Detail

Summary

• Symbol: Igf1^tm1.1Dlr
• Name: insulin-like growth factor 1; targeted mutation 1.1, Derek LeRoith
• MGI ID: MGI:2449287
• Synonyms: IGF-I -, KO-HIT
• Gene: Igf1 Location: Chr10:87694127-87772904 bp, + strand Genetic Position: Chr10, 43.7 cM
• Alliance: Igf1^tm1.1Dlr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49468
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Igf1^tm1Dlr in which the loxP flanked sequences were deleted in the germline by crossing mice carrying Igf1^tm1Dlr to mice carrying the TgN(EIIa-cre)C5379Lmgd transgene. A truncated, non functional protein is produced. (J:49468)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igf1 Mutation: 27 strains or lines available

References

• Original: J:49468 Liu JL, et al., Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice. Mol Endocrinol. 1998 Sep;12(9):1452-62
• All: 5 reference(s)