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Igf1tm1.1Dlr
Targeted Allele Detail
Nomenclature
Symbol: Igf1tm1.1Dlr
Name: insulin-like growth factor 1; targeted mutation 1.1, Derek LeRoith
MGI ID: MGI:2449287
Synonyms: IGF-I -, KO-HIT
Gene: Igf1  Location: Chr10:87858265-87937042 bp, + strand  Genetic Position: Chr10, 43.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49468
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele is a derivative of Igf1tm1Dlr in which the loxP flanked sequences were deleted in the germline by crossing mice carrying Igf1tm1Dlr to mice carrying the TgN(EIIa-cre)C5379Lmgd transgene. A truncated, non functional protein is produced. (J:49468)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf1 Mutation:  16 strains or lines available
References
Original:  J:49468 Liu JL, et al., Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice. Mol Endocrinol. 1998 Sep;12(9):1452-62
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory