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Targeted Allele Detail
Symbol: Pck1tm1.1Mgn
Name: phosphoenolpyruvate carboxykinase 1, cytosolic; targeted mutation 1.1, Mark A Magnuson
MGI ID: MGI:2449283
Synonyms: pcklox
Gene: Pck1  Location: Chr2:173153073-173159254 bp, + strand  Genetic Position: Chr2, 95.79 cM, cytoband C1-qter
Germline Transmission:  Earliest citation of germline transmission: J:63929
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThis allele is a derivative of Pck1tm1Mgn in which the loxP-flanked neomycin cassette was removed in single cells embryos by transient Cre expression. LoxP sites remain flanking exons 4 and 5 in the final allele. Activity and protein mass assays on protein derived from kidney and liver of fasted homozygous mice demonstrated that this allele behaves similar to the wild-type allele. (J:63929)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pck1 Mutation:  6 strains or lines available
Original:  J:63929 She P, et al., Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol Cell Biol. 2000 Sep;20(17):6508-17
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory