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Targeted Allele Detail
Symbol: Sbf1tm1Mlc
Name: SET binding factor 1; targeted mutation 1, Michael L Cleary
MGI ID: MGI:2449174
Synonyms: Sbf1-
Gene: Sbf1  Location: Chr15:89288236-89315311 bp, - strand  Genetic Position: Chr15, 44.79 cM, cytoband F1
Failure of spermatogenesis in Sbf1tm1Mlc/Sbf1tm1Mlc mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:76406
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exons 21-28 with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of brain extracts. Immunohistochemical analysis of seminferous tubules from homozygous mutant mice demonstrated absence of protein product in spermatogonia, pachytene spermatocytes, and Sertoli cells. (J:76406)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sbf1 Mutation:  22 strains or lines available
Original:  J:76406 Firestein R, et al., Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1. J Clin Invest. 2002 May;109(9):1165-72
All:  1 reference(s)

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MGI 6.11
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