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Targeted Allele Detail
Symbol: Ncoa6tm1.1Jkr
Name: nuclear receptor coactivator 6; targeted mutation 1.1, Janardan K Reddy
MGI ID: MGI:2448999
Synonyms: PRIP-
Gene: Ncoa6  Location: Chr2:155390665-155473894 bp, - strand  Genetic Position: Chr2, 77.26 cM, cytoband H2
Developmental retardation and abnormalities in Ncoa6tm1.1Jkr/Ncoa6tm1.1Jkr E12.5 mutants

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:81217
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsFloxed exon 7 was deleted via cre-mediated homologous recombination by mating Ncoa6tm1Jkr animals to the cre deleter strain TgN(EIIa-cre)C5379Lmgd. Homozygous mutant embryos were detected by PCR genotyping up to day E13.5 but did not survive until birth. (J:81217)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncoa6 Mutation:  70 strains or lines available
Original:  J:81217 Zhu YJ, et al., Coactivator PRIP, the Peroxisome Proliferator-activated Receptor-interacting Protein, Is a Modulator of Placental, Cardiac, Hepatic, and Embryonic Development. J Biol Chem. 2003 Jan 17;278(3):1986-90
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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