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Tg(ACTFLPe)9205Dym
Transgene Detail
Nomenclature
Symbol: Tg(ACTFLPe)9205Dym
Name: transgene insertion 9205, Susan Dymecki
MGI ID: MGI:2448985
Synonyms: ACTB:FLPe, ACTB::FLPe, ACTFlpe, ACT-FLPe, actin-FLPe, beta-actinFLPe, CAGG-Flpr, CAGGS-flp, Flp, Flp deleter, FLPe, hACTB-FLPe, hACTB::FLPe, TgaFlpe, TgpCAG-flpe
Transgene: Tg(ACTFLPe)9205Dym  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation details
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: ACTB     Summary of all recombinase alleles driven by ACTB.
 

Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Notes
The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being 4X and 10X that of wildtype FLP at 37C and 40C, respectively. Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.

References
Original:  J:78660 Rodriguez CI, et al., High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet. 2000 Jun;25(2):139-40
All:  548 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory