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Lrp5tm1Jsak
Targeted Allele Detail
Nomenclature
Symbol: Lrp5tm1Jsak
Name: low density lipoprotein receptor-related protein 5; targeted mutation 1, Juro Sakai
MGI ID: MGI:2448955
Synonyms: LRP5-
Gene: Lrp5  Location: Chr19:3584828-3686564 bp, - strand  Genetic Position: Chr19, 3.33 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81174
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 18 was disrupted by a neomycin selection cassette inserted by homologous recombination. Neither normal transcript nor normal protein was detected by Northern and Western blot analyses of liver tissue obtained from homozygous mutant mice. (J:81174)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp5 Mutation:  8 strains or lines available
References
Original:  J:81174 Fujino T, et al., Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):229-34
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory