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Tg(tetO-cre)LC1Bjd
Transgene Detail
Nomenclature
Symbol: Tg(tetO-cre)LC1Bjd
Name: transgene insertion LC1, Hermann Bujard
MGI ID: MGI:2448952
Synonyms: LC-1, LC1-Cre, TgLC1, TRE-LC1
Transgene: Tg(tetO-cre)LC1Bjd  Location: unknown  Genetic Position: Chr6, Syntenic
Transgene
origin
Strain of Origin:  (C57BL/6 x BALB/c)F2
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    induced by doxycycline
Mutation:    Insertion
 
Mutation detailsThe transgenic construct contained a bidirectional tTA/rtTA responsive promoter derived from the human cytomegalovirus promoter IE and flanked by sequence encoding luciferase and cre recombinase. Efficient cre mediated recombination, unaffected by position effect variegation, was demonstrated in hepatocytes. Transcription of in both directions was shown to be activated by rtTA in the presence of doxycycline. Transgene insertion is on chromosome 6C1 flanked by genes coding for the vomeronasal receptors V1rc14 and V1rc15 (K.Schonig, pers. commun.) (J:81196)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: tetO     Summary of all recombinase alleles driven by tetO.
 

Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.

References
Original:  J:81196 Schonig K, et al., Stringent doxycycline dependent control of CRE recombinase in vivo. Nucleic Acids Res. 2002 Dec 1;30(23):e134
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory