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Tlx2tm1Htno
Targeted Allele Detail
Nomenclature
Symbol: Tlx2tm1Htno
Name: T cell leukemia, homeobox 2; targeted mutation 1, Masahiko Hatano
MGI ID: MGI:2448951
Synonyms: Ncx-/-
Gene: Tlx2  Location: Chr6:83068324-83070293 bp, - strand  Genetic Position: Chr6, 35.94 cM, cytoband C3-D1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42356
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of a 0.9kb fragment containing the 5' upstream region and part of exon 1 with a neomycin resistance cassette via homologous recombination. (J:42356)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tlx2 Mutation:  6 strains or lines available
References
Original:  J:42356 Hatano M, et al., A novel pathogenesis of megacolon in Ncx/Hox11L.1 deficient mice. J Clin Invest. 1997 Aug 15;100(4):795-801
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory