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Fmn2tm1Led
Targeted Allele Detail
Nomenclature
Symbol: Fmn2tm1Led
Name: formin 2; targeted mutation 1, Philip Leder
MGI ID: MGI:2448909
Synonyms: Fmn2-
Gene: Fmn2  Location: Chr1:174501825-174822729 bp, + strand  Genetic Position: Chr1, 81.04 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81246
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by replacement of 1300 bp of the proline-rich exon with a neomycin resistance cassette via homologous recombination, introducing stop codons in all 3 reading frames. The deleted region encodes 433 amino acids and contains the FH1 domain. Northern blot analysis of brain RNA from homozygous mutants confirmed the absence of wild-type gene product. A partial read-through transcript containing the neomycin cassette was observed. (J:81246)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fmn2 Mutation:  41 strains or lines available
References
Original:  J:81246 Leader B, et al., Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes. Nat Cell Biol. 2002 Dec;4(12):921-8
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory