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Tg(SOD1)2Gur
Transgene Detail
Nomenclature
Symbol: Tg(SOD1)2Gur
Name: transgene insertion 2, Mark E Gurney
MGI ID: MGI:2448770
Synonyms: N1029, N29, SOD1WT, tg-SOD1, WTSOD1, WT SOD1
Transgene: Tg(SOD1)2Gur  Location: unknown  
Amyotrophic lateral sclerosis-like lesions in the spinal cord of Tg(SOD1)2Gur/0 and Tg(SOD1-G93A)1Gur/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(SOD1)2Gur expresses 1 gene
 
Mutation detailsThe transgene contains the normal allele of the human superoxide dismutase 1 gene (SOD1). Transgene expression in brain was confirmed by enzyme immunoassay using antibodies that recognize human SOD1 protein. (J:32665)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
Expression level of the wild-type transgene in transgenic animals is comparable to that in transgenic mice carrying the original highest expressing line Tg(SOD1*G93A)2Gur.

References
Original:  J:32665 Gurney ME, et al., Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation [see comments] [published erratum appears in Science 1995 Jul 14;269(5221):149]. Science. 1994 Jun 17;264(5166):1772-5
All:  105 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory