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Tg(APOB)1102Sgy
Transgene Detail
Nomenclature
Symbol: Tg(APOB)1102Sgy
Name: transgene insertion 1102, Stephen G Young
MGI ID: MGI:2448678
Synonyms: 1102, hApoB, TgN(hApoB)1102SY
Transgene: Tg(APOB)1102Sgy  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(APOB)1102Sgy expresses 1 gene
 
Mutation detailsThe transgene contains a 79.5 kb P1 insert with the entire human APOB gene. RNA slot blot analysis detected transgene expression in the liver, with very small amounts expressed in the small intestine and heart. Western blot analysis of plasma from transgenic animals showed human apo-B100 as the predominant species of transgene product. (J:81265)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
Founder 1102 carries 10 copies of the human APOB transgene and expresses the highest amount of transgene product. Nine other founder lines (4-42 copies of the transgene) were also established.
References
Original:  J:81265 Linton MF, et al., Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a). J Clin Invest. 1993 Dec;92(6):3029-37
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory