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Tg(Vil-cre)997Gum
Transgene Detail
Nomenclature
Symbol: Tg(Vil-cre)997Gum
Name: transgene insertion 997, Deborah L Gumucio
MGI ID: MGI:2448639
Synonyms: 12.4KbVilCre, Tg(Vil-cre)997Gum, Vcre, VilCre, Vil-Cre, Villin-cre, Villin.cre, VillinCre
Transgene: Tg(Vil-cre)997Gum  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsA 12.4-kb promoter fragment from the villin 1 gene drives the expression of cre recombinase. Recombination occurs in villi and crypt cells of the small and large intestines, closely patterning the endogenous gene expression. According to the corresponding author (J:78815), expression is generally continuous but a small amount of mosaicism is noted in the colon. Onset of transgene expression is at 12.5 dpc, which is delayed from the endogenous mouse Vil gene expression onset of 9.0 dpc. (J:78815)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Vil1     Summary of all recombinase alleles driven by Vil1.
 

Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 34 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.

References
Original:  J:78815 Madison BB, et al., cis Elements of the Villin Gene Control Expression in Restricted Domains of the Vertical (Crypt) and Horizontal (Duodenum, Cecum) Axes of the Intestine. J Biol Chem. 2002 Sep 6;277(36):33275-83
All:  195 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/28/2015
MGI 5.21
The Jackson Laboratory