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Ebi3tm1Rsb
Targeted Allele Detail
Nomenclature
Symbol: Ebi3tm1Rsb
Name: Epstein-Barr virus induced gene 3; targeted mutation 1, Richard Blumberg
MGI ID: MGI:2448308
Synonyms: EBI-3, EBI3-, Ebi3tm1Birk, EBI3tm Birk
Gene: Ebi3  Location: Chr17:56259640-56264022 bp, + strand  Genetic Position: Chr17, 29.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81014
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encompassing exons 2 through 5 was replaced by a neomycin selection cassette inserted by homologous recombination. Northern blot analysis of splenic RNA indicated an absence of normal transcript in homozygous mutant mice. (J:81014)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ebi3 Mutation:  9 strains or lines available
References
Original:  J:81014 Nieuwenhuis EE, et al., Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16951-6
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory