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Targeted Allele Detail
Symbol: Mrc1tm1Mnz
Name: mannose receptor, C type 1; targeted mutation 1, Michel C Nussenzweig
MGI ID: MGI:2448258
Synonyms: CD206-, MMR-, MR-
Gene: Mrc1  Location: Chr2:14229414-14332023 bp, + strand  Genetic Position: Chr2, 10.46 cM
Germline Transmission:  Earliest citation of germline transmission: J:75364
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsExon 1 was disrupted by an enhanced green fluorescent protein (eGFP) gene inserted at the endogenous start codon. A single loxP site remained downstream of eGFP after the removal of a floxed neo cassette. Western blot analysis of lymph node lysates indicated an absence of normal protein in homozygous mutant mice. (J:75364)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mrc1 Mutation:  2 strains or lines available
Original:  J:75364 Lee SJ, et al., Mannose receptor-mediated regulation of serum glycoprotein homeostasis. Science. 2002 Mar 8;295(5561):1898-901
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory