Foxm1^tm1Rhc
Targeted Allele Detail

Summary

• Symbol: Foxm1^tm1Rhc
• Name: forkhead box M1; targeted mutation 1, Robert H Costa
• MGI ID: MGI:2448247
• Synonyms: Foxm1b^-, Foxm1b fl, Foxm1^fl, Foxm1^flox, FoxM1^flox
• Gene: Foxm1 Location: Chr6:128339957-128352849 bp, + strand Genetic Position: Chr6, 62.98 cM
• Alliance: Foxm1^tm1Rhc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81015
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was introduced into intron 3 and a floxed PGK-neo cassette was introduced downstream of exon 7 through homologous recombination. (J:81015)

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Foxm1^tm1Rhc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxm1 Mutation: 26 strains or lines available

Notes

ES cell line was not specified; strain was reported as 129SvJ.

References

• Original: J:81015 Wang X, et al., The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16881-6
• All: 49 reference(s)