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Targeted Allele Detail
Symbol: Adam12tm1Asf
Name: a disintegrin and metallopeptidase domain 12 (meltrin alpha); targeted mutation 1, Atsuko Sehara-Fujisawa
MGI ID: MGI:2448241
Synonyms: Meltrin alpha-
Gene: Adam12  Location: Chr7:133883199-134225097 bp, - strand  Genetic Position: Chr7, 77.61 cM, cytoband F4
Germline Transmission:  Earliest citation of germline transmission: J:81009
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exon 1 with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by RT-PCR analysis of day E14.5 homozygous mutant embryos. Primers directed against the metalloprotease, disintegrin, cysteine-rich, and cytoplasmic domains did not detect any gene expression. (J:81009)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam12 Mutation:  24 strains or lines available
Original:  J:81009 Kurisaki T, et al., Phenotypic analysis of Meltrin alpha (ADAM12)-deficient mice: involvement of Meltrin alpha in adipogenesis and myogenesis. Mol Cell Biol. 2003 Jan;23(1):55-61
All:  9 reference(s)

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MGI 6.13
The Jackson Laboratory