Cuzd1^tm1Ljm
Targeted Allele Detail

Summary

• Symbol: Cuzd1^tm1Ljm
• Name: CUB and zona pellucida-like domains 1; targeted mutation 1, Louis J Muglia
• MGI ID: MGI:2448160
• Synonyms: Itmap1^-
• Gene: Cuzd1 Location: Chr7:130910283-130924021 bp, - strand Genetic Position: Chr7, 73.81 cM
• Alliance: Cuzd1^tm1Ljm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80980
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and 1.6 kb of upstream sequence was replaced with a PGK-neo cassette inserted by homologous recombination. Northern blot analysis of uterine RNA obtained from pregnant homozygous mutant mice indicated an absence of normal transcript. Endogenous protein was undetected by Western blot analysis of total membrane extracts from homozygous mutant pancreatic and uterine tissues. (J:80980)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cuzd1 Mutation: 44 strains or lines available

References

• Original: J:80980 Imamura T, et al., Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1. J Biol Chem. 2002 Dec 27;277(52):50725-33
• All: 1 reference(s)