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Nrg1tm2Zhou
Targeted Allele Detail
Nomenclature
Symbol: Nrg1tm2Zhou
Name: neuregulin 1; targeted mutation 2, Mingdong Zhou
MGI ID: MGI:2448078
Gene: Nrg1  Location: Chr8:31814551-32884029 bp, - strand  Genetic Position: Chr8, 18.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81106
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe majority of exon 11 and a portion of intron 11 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the transmembrane domain. (J:81106)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrg1 Mutation:  20 strains or lines available
Notes
ES cell line = CJ1 (J:81106).
References
Original:  J:81106 Stefansson H, et al., Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet. 2002 Oct;71(4):877-92
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory