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Targeted Allele Detail
Symbol: Nrg1tm1Fej
Name: neuregulin 1; targeted mutation 1, Frank E Jones
MGI ID: MGI:2448075
Synonyms: HRGalpha-null
Gene: Nrg1  Location: Chr8:31814551-32884254 bp, - strand  Genetic Position: Chr8, 18.75 cM
Germline Transmission:  Earliest citation of germline transmission: J:81107
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThe endogenous locus was modified to contain a stop codon in exon 7 and single loxP sites flanking exons 7, 8, and 9. The mutation was designed to specifically target the alpha isoform, which contains exon 7. RT-PCR analysis showed reduced levels of mRNA, putatively due to nonsense mediated decay. (J:81107)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrg1 Mutation:  2 strains or lines available
Original:  J:81107 Li L, et al., The breast proto-oncogene, HRGalpha regulates epithelial proliferation and lobuloalveolar development in the mouse mammary gland. Oncogene. 2002 Jul 25;21(32):4900-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory