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Bmp3tm1Kml
Targeted Allele Detail
Nomenclature
Symbol: Bmp3tm1Kml
Name: bone morphogenetic protein 3; targeted mutation 1, Karen M Lyons
MGI ID: MGI:2448071
Synonyms: Bmp3-
Gene: Bmp3  Location: Chr5:98854415-98884396 bp, + strand  Genetic Position: Chr5, 48.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75187
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 3.8 kb fragment containing exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded most of the precursor region, the proteolytic processing site, and two thrids of the mature region. RT-PCR analysis indicated an absence of normal transcript in homozygous mutant mice. (J:75187)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bmp3 Mutation:  8 strains or lines available
References
Original:  J:75187 Daluiski A, et al., Bone morphogenetic protein-3 is a negative regulator of bone density. Nat Genet. 2001 Jan;27(1):84-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory