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Tns2nph
Spontaneous Allele Detail
Nomenclature
Symbol: Tns2nph
Name: tensin 2; nephrosis
MGI ID: MGI:2447990
Synonyms: nep
Gene: Tns2  Location: Chr15:102102988-102116401 bp, + strand  Genetic Position: Chr15, 57.29 cM
Mutation
origin
Strain of Origin:  ICR
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsA phenotypic mutant that arose in an outbred ICR colony at the National Institute of Health (Japan) in 1986. This is the main causative gene producing nephrosis in the ICGN strain. An 8 base pair deletion in exon 18 (from nucleotide 1477 to nucleotide 1484) is predicted to result in a premature stop codon and protein truncation. Tenc1 expression is significantly decreased in all organs of ICGN animals. (J:108691)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tns2 Mutation:  4 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Nephrotic Syndrome (J:21656)

References
Original:  J:16284 Kurosawa T, et al., Nephrosis (nep): a new mouse mutation which causes albuminuria and other symptoms of nephrosis. Mouse Genome. 1993;91(4):876-78
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory