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Clcn3tm1Lamb
Targeted Allele Detail
Nomenclature
Symbol: Clcn3tm1Lamb
Name: chloride channel, voltage-sensitive 3; targeted mutation 1, Fred S Lamb
MGI ID: MGI:2447864
Synonyms: Clcn3-
Gene: Clcn3  Location: Chr8:60910389-60983300 bp, - strand  Genetic Position: Chr8, 30.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80901
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encompassing a portion of exon 6 and all of exon 7 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded a portion of transmembrane domain 2 and all of transmembrane domains 3 and 4. Protein was undetected by Western blot analysis of brain tissue obtained from homozygous mutant mice. (J:80901)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clcn3 Mutation:  96 strains or lines available
References
Original:  J:80901 Dickerson LW, et al., Altered GABAergic function accompanies hippocampal degeneration in mice lacking ClC-3 voltage-gated chloride channels. Brain Res. 2002 Dec 27;958(2):227-50
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory