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Targeted Allele Detail
Symbol: Igf2rtm1.1Rlj
Name: insulin-like growth factor 2 receptor; targeted mutation 1.1, Randy L Jirtle
MGI ID: MGI:2447858
Gene: Igf2r  Location: Chr17:12682406-12769664 bp, - strand  Genetic Position: Chr17, 8.64 cM, cytoband A-C
Germline Transmission:  Earliest citation of germline transmission: J:80932
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe floxed fragment containing exon 10 was excised from Igf2rtm1Rlj via in vivo cre mediated recombination. Sequence analysis indicated that the deletion of exon 10 will cause a shift in the open reading frame resulting in a stop codon upstream of the mannose 6-phosphate binding site, the Igf2 protein product binidng site, and the transmembrane domain. While, protein was undetected in mutant embryos by Western blot analysis, immunohistochemical analysis showed protein expression in developing bronchiolar structures. This staining putatively represents expression from an unsilenced paternal allele. (J:80932)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf2r Mutation:  47 strains or lines available
Original:  J:80932 Wylie AA, et al., Tissue-specific inactivation of murine M6P/IGF2R. Am J Pathol. 2003 Jan;162(1):321-8
All:  1 reference(s)

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MGI 6.11
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