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Tg(RHO-SCA7)R7EJman
Transgene Detail
Nomenclature
Symbol: Tg(RHO-SCA7)R7EJman
Name: transgene insertion R7E, Jean-Louis Mandel
MGI ID: MGI:2447845
Synonyms: R7E
Transgene: Tg(RHO-SCA7)R7EJman  Location: unknown  
Aberrant retinal rod chromatin remodeling and segment loss in Tg(RHO-SCA7)R7EJman/0 mice compared to normal retinas in Tg(RHO-SCA7)R7NJman/0 mice

Show the 2 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  C57BL/6 x SJL
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(RHO-SCA7)R7EJman expresses 1 gene
 
Mutation detailsThe transgene consists of a human rhodopsin promoter (containing the RER enhancer element), the full-length mutant human Sca7 gene carrying a 90 glutamine repeat expansion, and an SV40 intron and polyadenylation sequence. Transgene expression was observed in rod cells by immunofluorescence, and in retinal extracts by Western blot. (J:65411)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Transgenic lines A, B, C, D, and F were constructed. Line A carries 10-50 copies of the integrated transgene and line F carries 1-5 copies. Lines A and F express the highest amount of transgene product and were used for analysis.
References
Original:  J:65411 Yvert G, et al., Expanded polyglutamines induce neurodegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice. Hum Mol Genet. 2000 Oct 12;9(17):2491-506
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory