About   Help   FAQ
Stat2tm1Shnd
Targeted Allele Detail
Nomenclature
Symbol: Stat2tm1Shnd
Name: signal transducer and activator of transcription 2; targeted mutation 1, Christian Schindler
MGI ID: MGI:2447829
Synonyms: Stat2-/-
Gene: Stat2  Location: Chr10:128270559-128292849 bp, + strand  Genetic Position: Chr10, 76.5 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66564
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exons 1-4 with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by Western blot analysis of primary mouse embryonic fibroblast (PMEF) extracts prepared from homozygous mutant embryos. Stat1 expression was reduced by 50% in Stat2-deficient cells. (J:66564)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Stat2 Mutation:  8 strains or lines available
References
Original:  J:66564 Park C, et al., Immune response in Stat2 knockout mice. Immunity. 2000 Dec;13(6):795-804
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/29/2020
MGI 6.15
The Jackson Laboratory