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Targeted Allele Detail
Symbol: Stat2tm1Shnd
Name: signal transducer and activator of transcription 2; targeted mutation 1, Christian Schindler
MGI ID: MGI:2447829
Synonyms: Stat2-/-
Gene: Stat2  Location: Chr10:128270559-128292849 bp, + strand  Genetic Position: Chr10, 76.5 cM
Germline Transmission:  Earliest citation of germline transmission: J:66564
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exons 1-4 with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by Western blot analysis of primary mouse embryonic fibroblast (PMEF) extracts prepared from homozygous mutant embryos. Stat1 expression was reduced by 50% in Stat2-deficient cells. (J:66564)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Stat2 Mutation:  8 strains or lines available
Original:  J:66564 Park C, et al., Immune response in Stat2 knockout mice. Immunity. 2000 Dec;13(6):795-804
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory