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Mvptm1Wie
Targeted Allele Detail
Nomenclature
Symbol: Mvptm1Wie
Name: major vault protein; targeted mutation 1, Erik A C Wiemer
MGI ID: MGI:2447742
Synonyms: MVP-
Gene: Mvp  Location: Chr7:126986860-127014621 bp, - strand  Genetic Position: Chr7, 69.26 cM, cytoband F4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80831
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exons 5-7 with a neomycin resistance cassette via homologous recombination. Absence of gene expression was confirmed by Northern and Western blot analysis. Gene transcript was not detectable in liver RNA from homozygous mutant animals, and protein product was not observed in several tissues tested. (J:80831)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mvp Mutation:  45 strains or lines available
References
Original:  J:80831 Mossink MH, et al., Disruption of the murine major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics. Cancer Res. 2002 Dec 15;62(24):7298-304
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory