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Tg(Mpz)80.4Wra
Transgene Detail
Nomenclature
Symbol: Tg(Mpz)80.4Wra
Name: transgene insertion 80.4, Lawrence Wrabetz
MGI ID: MGI:2447698
Synonyms: Tg80.4, Tg(Mpz)24Mes
Transgene: Tg(Mpz)80.4Wra  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe entire Mpz gene (including 6 kb of promoter sequences, all exons and introns, and the natural polyadenylation site) was used as the transgene. Transgenic line 80.4 carries 14 copies of the integrated transgene. Transgene overexpression is approximately 0.8-fold that of the endogenous protein. (J:78758)
Phenotypes
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:78758 Wrabetz L, et al., P(0) glycoprotein overexpression causes congenital hypomyelination of peripheral nerves. J Cell Biol. 2000 Mar 6;148(5):1021-34
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory