Tg(Thy1-cre/PGR*)1Gsc
Transgene Detail

Summary

• Symbol: Tg(Thy1-cre/PGR*)1Gsc
• Name: transgene insertion 1, Gunther Schutz
• MGI ID: MGI:2447655
• Synonyms: Tg(Thy1-cre/PGR)1Gsc, TPR1
• Transgene: Tg(Thy1-cre/PGR*)1Gsc Location: unknown
• Alliance: Tg(Thy1-cre/PGR*)1Gsc page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: mifepristone
• Mutation: Insertion
• Tg(Thy1-cre/PGR*)1Gsc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Thy1 (MGI:98747)

• Mutation details: This transgene expresses a fusion protein consisting of Cre recombinase and a modified ligand-binding domain of the human progesterone receptor under the control of a mouse Thy1 promoter. The ligand-binding domain was modified such that it binds and can be activated by the synthetic steroid, RU486, but not the endogenous ligand, progesterone. Upon induction of transgene expression with RU486, activity was noted in the hippocampus and cortex. The activity was also noted in small populations of cells in the inferior colliculus, the striatum, the thalamus, the brain stem, and the cerebellum. (J:69323, J:84610)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Thy1 (mouse) Summary of all recombinase alleles driven by Thy1. Comparative matrix view of recombinase activities Alliance mouse Thy1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:69323 Kellendonk C, et al., Inducible site-specific recombination in the brain. J Mol Biol. 1999 Jan 8;285(1):175-82
• All: 2 reference(s)