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Dlx5/Dlx6tm1Levi
Targeted Allele Detail
Nomenclature
Symbol: Dlx5/Dlx6tm1Levi
Name: distal-less homeobox 5; targeted mutation 1, Giovanni Levi
MGI ID: MGI:2447624
Synonyms: Dlx5/6-, Dlx5-Dlx6-
Gene: Dlx5  Location: Chr6:6877805-6882085 bp, - strand  Genetic Position: Chr6, 2.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77244
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsCoding regions of both Dlx5 and Dlx6 were deleted and replaced with lacZ-floxed-RSV-neo construct via a single homologous recombination event. The gene targeting event also generated a transcriptionally silent genomic duplication spanning both Dlx5 and Dxl6. Absence of gene expression was confirmed by RT-PCR and whole mount in situ hybridization. (J:77244)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dlx5 Mutation:  8 strains or lines available
References
Original:  J:77244 Merlo GR, et al., Mouse model of split hand/foot malformation type I. Genesis. 2002 Jun;33(2):97-101
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory