About   Help   FAQ
Tg(hAGT)2041Sig
Transgene Detail
Nomenclature
Symbol: Tg(hAGT)2041Sig
Name: transgene insertion 2041, Curt Sigmund
MGI ID: MGI:2447399
Synonyms: 204/1 line, A+, hAng, Hu-AGT-TG
Transgene: Tg(hAGT)2041Sig  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL/J)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(hAGT)2041Sig expresses 1 gene
 
Mutation detailsThe 14 kb transgenic construct contained the entire human angiotensinogen gene (approximately 11.5 kb) and 5' (1.2 kb) and 3' (1.4 kb) flanking sequence. Sequence analysis showed that the construct contained the M235T variant but not the T174M variant. The human AGT promoter drove high levels of expression in the liver and kidney. Expression was also detected in the heart, adrenal gland, and adipose tissue, and at very low levels in the brain and submandibular gland. Sexually dimorphic expression, in which expression was higher in males, was observed in the kidney and adrenal gland. Lines 204.1 (2041) and 204.3 (2043) were created and transgenic mice on a C57BL/6 background show angiotensinogen plasma concentrations 150X that normally found in human plasma. (J:79944)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:79944 Yang G, et al., Functional expression of the human angiotensinogen gene in transgenic mice. J Biol Chem. 1994 Dec 23;269(51):32497-502
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/13/2021
MGI 6.16
The Jackson Laboratory